Alzheimers Disease Treatment by Nemanda, Memantine

treatment of alzheimers disease with memantine - nemanda

Treating Alzheimer’s Disease with Namenda

Namenda®(memantine HCl) approved by the FDA on October 16, 2003, represents an important advance in the treatment of Alzheimer’s disease. Namenda is the first and only medication approved to treat moderate to severe Alzheimer’s disease. It works in an entirely different way than currently available medications and has been proven effective, with use in more than 1 million people worldwide. Talk to your doctor about Namenda, the innovative therapy option for the lives touched by Alzheimer’s disease.




Why to Consider Namenda?

There is no treatment that can stop the progressive, damaging changes that take place in the brain as a result of Alzheimer’s disease. But ground-breaking clinical studies have shown that Namenda is effective when used alone or in combination with donepezil.

Namenda can be used by itself, or in combination with the medication donepezil. In studies of patients with moderate to severe Alzheimer’s disease, those who took Namenda by itself showed a slower decline in mental function when compared with those who took a sugar pill. In a separate study, those who took Namenda in combination with donepezil, vs. donepezil alone, also showed a slower decline in mental function.

Talk to a doctor about whether Namenda may be the right treatment choice.



How Namenda Works for Alzheimer’s Disease?

Glutamate: A Key to Storing and Processing Information

Researchers of Alzheimer’s Disease believe that certain nervous system receptors in the brain may be responsible for the symptoms of Alzheimer’s disease. The scientific name for these receptors is N-methyl-D-aspartate or NMDA. Researchers believe that glutamate, a specialized messenger chemical involved in processing, storing, and retrieving information, can increase the activity of these receptors. It is believed that in Alzheimer’s disease, the activity of glutamate is not regulated correctly, resulting in the signs and symptoms of Alzheimer’s disease.

Mementine- Nemanda for Alzheimer Disease

The Role of Glutamate and Calcium




Glutamate affects learning and memory functions because it triggers NMDA receptors to allow the right amount of calciumto flow into a nerve cell. When the right amount of glutamate and calcium are available, it helps create the chemical environment that the brain needs to store information. If there is not enough glutamate, the chemical environment is not created, and information cannot be stored. On the other hand, if too much glutamate is available, too much calcium may be allowed to flow into the nerve cells, and the nerve cells may die.

Regulating Glutamate with Namenda

Namenda has been shown to be an effective treatment for the symptoms of moderate to severe Alzheimer’s disease. It works differently than other currently available therapies. It is believed to work by attaching to the NMDA receptors in the brain and regulating the activity of glutamate, helping to ensure that the right amount of glutamate is available. The right amount of glutamate helps create the chemical environment needed for the brain to process, store, and retrieve information, resulting in learning and memory.

It’s important to remember that no medication, including Namenda, has been developed to stop the damaging changes in the brain that result in memory loss, as well as changes in behavior and personality.

Talk to a doctor about whether Namenda may be the right treatment choice for you or your Alzheimer’s sufferer.



 

About Daily Namenda Therapy used for Alzheimer’s Disease

Namenda is supplied in the form of a tablet that is taken twice daily. Therapy begins at 5 mg and gradually increases to the target dose of 10 mg twice/day. Namenda is available in 5 and 10 mg tablets, so a combination of tablets is needed to gradually increase therapy.

The schedule below shows the recommended daily dose and number of doses per day for the 4-week starting period. When the daily dose has reached 20 mg (i.e., 10 mg, twice a day), patients taking Namenda can continue with that daily regimen, unless instructed otherwise by their doctor.

Ask your loved one’s doctor about the Namenda Patient Starter Kit and Titration Pak. This special starter pack takes the guesswork out of starting Namenda therapy.

Namenda: Easy to Start With, Easy to Stay With

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To be effective, NAMENDA must be taken correctly, according to the following schedule:




Week 1: Start on Day 1.
Take one 5 mg tablet in the morning, each day.

Week 2: Start on Day 8.
Take one 5 mg tablet in the morning and one 5 mg tablet at night, each day.

Week 3: Start on Day 15.
Take one 10 mg tablet in the morning and one 5 mg tablet at night, each day.

Week 4: Start on Day 22.
Take one 10 mg tablet in the morning and one 10 mg tablet at night, each day.

Week 5 and Beyond: 
The recommended dose is 10 mg taken twice a day.

After completing the Namenda Patient Starter Kit and Titration Pak, you will need to fill a new prescription to continue on the maintenance dose of 10 mg, twice daily.

Namenda can be taken with or without food.

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Side Effects of Namenda Treatment for Alzheimer’s Disease

Namenda®(memantine HCl) has been shown to be an effective treatment for the symptoms of moderate to severe Alzheimer’s disease. It works differently than other currently available therapies. It is believed to work by attaching to the NMDA receptors in the brain and regulating the activity of glutamate, helping to ensure that the right amount of glutamate is available. The right amount of glutamate helps create the chemical environment needed for the brain to process, store, and retrieve information, resulting in learning and memory.

Namenda is the first and only medication approved to treat moderate to severe Alzheimer’s disease. Namenda has been used by more than 1 million people.

Namenda is well tolerated by most people but, remember that all drugs may cause side effects. The number of people taking Namenda who experienced side effects was almost equal to those taking a sugar pill. The most common side effects reported were dizziness, confusion, headache, and constipation. If you or your Alzheimer’s sufferer experience side effects, please contact your healthcare provider.

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