High Density Lipoprotein Cholesterol

hdl function

Lifestyle medicine is the use of lifestyle interventions directed at the treatment management and prevention of disease hey folks I want to take a minute to talk to you out.

HDL or high-density lipoprotein you may have heard it called HDL cholesterol is one of the biomarkers of your typical lipid profile and it’s important understand because has direct consequences on your health.

Especially cardiovascular disease.

Your body manages storage metabolizes fat through molecules collectively referred to as lipoproteins.


Categories of Lipoproteins

categories of lipoprotein

Technically speaking there are five different categories.


Very Low-Density Lipoproteins

Intermediate Density Lipoproteins

Low-Density Lipoproteins or LDL 

High-Density Lipoproteins

In this Articke, we are going to discuss about

HDL or High-Density Lipoprotein

As the name lipoprotein suggests they


Functions of Lipoproteins

Contain both lipids which are fat and proteins

This gives them both structure and function

Lipids normally do not like water and that is to say that they are hydrophobic but attach them to proteins makes them less so.

This allows them to move better around the body more effectively for various purposes.

We are made up of 60% water and so the purpose of lipoprotein is to transport the things that contain around the body.

Generally speaking lipoproteins contain varying amounts of five different molecular structures.





Cholesterol esters

HDL contains approximately 33% protein 30% cholesterol 30% phospholipids and a mix of the rest.

It has the highest density hence the name and the highest protein content that many of the phospholipids.


HDL Funtion

The purpose of HDL is to transforms content back to the liver for metabolism.

It is produced in the liver then it’s released into the bloodstream where it circulates and picks up cholesterol and phospholipids. This term is called reverse transport

Because it brings them back to the source which is the liver, once at the liver that can either be broken down for energy if your body needs it or excreted with bile into the gastrointestinal tract.

HDL also plays a role in delivering cholesterol to the adrenal glands testes and ovaries for synthesis of different steroid molecules.


HDL and Atherosclerosis

The reason that HDL plays an important role in cardiovascular health is because it can help stop or reverse atherosclerosis in plaque that builds in your arteries.

A specific type of immune cell called a macrophage have a tendency to gobble up cholesterol and triglycerides when they’re in excess in the bloodstream.

Which is one reason why doctors recommend low-fat diets for certain people.

Once filled with lipids or this so-called lipid Laden macrophages can end up getting deposited on damaged arterial walls leading to plaque buildup and ultimately atherosclerosis.

In atherosclerosis has a direct link to heart attack and stroke.

What HDL does is it helps in the same way as I mentioned before it picks up the cholesterol the phospholipids and those triglycerides and brings them back to liver reducing the plaque buildup in your blood vessels.


HDL and Disease

HDL has also additional properties that include:


Protection against thrombosis or blood clots

Maintenance of endothelial function and

Maintenance of low blood viscosity

The mechanism of these actions are not as well understood at this time.




Many studies have linked a low HDL to an increased risk of heart attack and stroke there are many things that can cause you to have low HDL.



Being Sedentary

and low physical activity

all have been associated with low HDL score.

Some individuals or families also have genetic disability means that for one reason or other do not allow them to produce HDL or to use a lot utilize it appropriately.


How to Increase your HDL?

There are many ways in which you can attempt to improve your lipid profile overall including increasing your HDL.

These include quitting smoking losing weight and exercising more.

Diets also very important

Diets high in mono and polyunsaturated fats and low in trans and saturated fats have been shown to improve your HDL.

Drinking alcohol in moderation also has a positive impact on your HDL cholesterol.

There are pharmaceutical options that you can talk to your doctor about if the lifestyle interventions don’t work.


The target HDL value

For men and women is a60 or more milligrams per deciliter.

The average for men is 40 to 50 and for women it’s 50 to 60.

Then low is considered to be less than 40 in men and less than 50 and women.

That criteria can vary slightly from one set of guidelines to the next.

So in summary HDL is a lipoprotein that is responsible for bringing facts back to the liver for metabolism.

Is protective against chlorosis which leads to heart attacks and strokes.

A low HDL increases your risk of heart attack and stroke and there are many ways that you can try to improve your HDL .

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